marina

In silico studies

Mutation frequence assay

Biofilm Inhibition assay

Post-antibiotic effect assay

DEC

NOV

OCT

M3

M2

M1

M1 - Evaluate the antimicrobial activity of the molecules M2 - Evaluate the citotoxicity and potential anticancer activity. If confirmed the anticancer activity, apoptosis assay will be performed. M3 - Write and submission of the article

Analysis and report

cITOTOXICITY AND

Paper's write

Development of hybrid molecules of fluoroquinolones and phenothiazines and evaluation of their antimicrobial and cytotoxic properties.

Analysis citotoxicity results

Analysis antimicrobial activity results

Citotoxicity evaluation NHDF

Citotoxicity LNCaP

Citotoxicity CACO-2

Apoptosis evaluation - Annexin V and propidium iodide labling

Citotoxicity MCF-7

SEP

AUG

JUL

JUN

MAY

APR

MAR

FEB

JAN

DEC

NOV

OCT

ANTIMICROBIAL ACTIVITY

Q5

Q4

Efflux pump inhibition assay

Q3

Q2

Q1