stem cell therapy

Salma Hosam Ahmed Saaed

IPSF RESEARCH LAB

using stem cells as potential cure for diabetes meletus

FUTURE APPLICATION

Expected findings

Conclusions

Methodology

RESEARCH GAPS

index

RESEARCH GAPS

The pathophysiology of T1D is not yet fully understood, partly because a suitable animal model for studying T1D does not exist. Experiments using SC-islet from patients with T1D may help researchers to understand the pathophysiology of T1D.

Solutions to Autoimmune responce to stem cells post transplatation.

immune rejection

Pathophysiology of TD1

EXPECTED FINDINGS

Autologous transplatation

immune modulation

Identifying beta cell phenotypes, specific markers for each cell subpopulation, and the mechanisms underlying their regulation will advance our understanding of beta cell function.

Methodology

Patients newly diagnosed with type 1 diabetes18–40 years of ageRandomization without any blocking restriction was performed

Procedures and variables

All patients received intensive insulin therapy (i.e., four or more injections per day) with insulin apart and insulin detemir on the basis of patient-measured blood glucose levels, as well as by continuous glucose monitoring performed on two occasions during the year. Target levels of plasma glucose were between 5 and 8 mmol/L, and HbA1c had a target level of <7.0% (53 mmol/mol).

Population

FUTURE APPLICATIONS

Studies on pure hPSC and keeping appropriate islet architecture to maintain functionality in comparison to healthy pancreatic cells would contribute to enhancing the quality of hPSC-derived beta cell. Additionally, since beta cell heterogeneity exists in normal human islet, it may be of interest to establish similar heterogeneity in vitro. Identifying beta cell phenotypes, specific markers for each cell sub-type, and their mode of action will enhance our understanding of how their in vivo maturation may be attained.

Conclusions

Stem cell therapy is the future of diabetic therapy which offer a great alternative for current treatments so the development of solutions to current problems facing its application on a larger scale is a major concern. Despite these obstacles, the application of stem cell-based therapy for T1DM represents the most advanced approach for curing type 1 diabetes.

CONCLUSION

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