Amine Functional group
1830
1900
1856
1849
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1887
1879
1894
1901
1910
1924
aniline
methylamine
Mauveine
phenylalanine
cocaine
Amphetamine
1834
cytosine
Adrenalin
dopamine
heroin
Fernanda Romero 3 Bcc
- Friedlieb Ferdinand Runge, synthesizes the dye aniline blue - Aniline is applied in the manufacture of dyes, medicines, photographic chemicals, perfumes, - Aniline is the simplest aromatic amine. It is formed by: a phenyl group attached to an amino group. - Formula: [ C6H5NH2 ]
- William H. Perkin, an English chemist who "accidentally" developed a dye with a (bad) purple hue, patented it that year as aniline purple. - Synthetic dye more intense than the natural one, at that time it gave way to a massive and cheaper production of the dye in full expansion of the textile industry. - Composed of 2 molecules of aniline, one of p-toluidine and one of o-toluidine. (Including primary and secondary amine). - Formula: [ (C26H23N4+X−) ]
- Tomás Moreno y Maiz published a doctoral thesis at the University of Paris, on coca, cocaine and their effects. - Used for its action as a local anesthetic and for its activating effects until it was banned in the medical field, - Contains cinnamylcocaine, benzoylecgonine, truxiline, as well as the related alkaloid, tropacocaine. Having ester, amine and arene. - Formula: [ C17H21NO4 ]
- Schulze and Barbieri made the first description of phenylalanine when they identified a compound with an empirical formula in yellow lupine seedlings. - Essential amino acid in the treatment of vitiligo, it is also an essential component of body tissues. With the ability to enhance the production of melanin by melanocytes. - Aromatic amino acid whose R group contains a benzene ring. In its structure it has an amine and carboxyl group. - Formula: [ C9H11NO2 ]
- Albrecht Kossel discovered cytosine in 1894 when it was hydrolyzed from calf thymus tissues. In 1903 its structure was established and it was synthesized (and thus confirmed) in the laboratory the same year. - Cytokines are small proteins that are crucial in controlling the growth and activity of other cells of the immune system and blood cells. When released, they send a signal to the immune system to do its job. - Pyrimidine derivative, with an aromatic ring and an amino group in position 4 and a ketone group in position - Formula: [ C4H5N3O ]
- A few years after it was first produced in a laboratory, at the end of the 19th century, heroin was the main ingredient in a cough remedy. - In the United States, exhaustive control over the use of opiates was established through the Drug Tax Act of 1914, allowing the use of heroin only for therapeutic purposes. Ten years later, in 1924, the United States Congress established that there was no legal use for heroin, so it prohibited its sale and manufacture, Even so, heroin production was large and continuous. - Heroin is made from morphine, a natural substance and has an amine, 2 ester groups and an ether. - Formula: [ C21H23NO5 ]
- Dopamine was first artificially synthesized in 1910 by George Barger and James Ewens at the Wellcome Laboratories in London. - Is a medication used to treat circulatory shock and blood hypotension. At low doses, it is used to increase blood flow to the kidneys. - Composed of a benzene ring with this amine group makes it a substituted phenethylamine and hydroxyl group. - Formula: [ C8H11NO2 ]
- The Romanian chemist Lazăr Edeleanu first synthesized Amphetamine - Used as an agent to improve performance, both physical and intellectual. It has been used therapeutically as an anorexigen, - Noted for its use as a designer drug for consumption. -They are sympathomimetic amines, with a structural chemical formula similar to adrenaline. - Formula: [ C9H13N ]
- Charles-Adolphe Wurtz first prepared methylamine by hydrolysis of methyl isocyanate and related compounds. - Used to prepare some chemical products, such as: pharmaceuticals, pesticides, solvents, cleaning agents, etc. - Methylamine is a good nucleophile because it is highly basic and free. - It is the simplest primary amine and is an organic compound in which an H atom is replaced by a methyl group. - Formula: [ CH3NH2 ]
- The Japanese Jōkichi Takamine was the one who, in 1901, discovered adrenaline, and with this discovery, the first hormone was known. - Adrenaline activates the circulatory system, improves the capacity of the respiratory system by dilating the bronchi, stimulates the production of dopamine, one of the happiness hormones, etc. - It is activated when we face situations of risk or certain danger and it is common to release while we practice risky sports. - In it you can see 3 hydroxyl groups in its structure and an amine. - Formula: [ C₉H₁₃NO₃ ]
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2010
2020
1987
1969
1972
1999
1959
1943
1930
2000
2000
tenamphetamine
Streptomycin
adenine
homocysteine
Amoxicillin
fluoxetine
Abacavir
dopamine
eribulin
Psilocybin
- Chemist Gordon A. Alles made the discovery and publication of the physiological effects of amphetamine and tenamphetamine. - Used as a recreational drug, and as a tool to complement different types of transcendental practices, psychonautics. - Contains the amine group. - Formula: [ C10H13NO2 ]
- Albert Schatz discovered streptomycin in 1943, the second useful antibiotic in the history of humanity. - It works by inhibiting bacterial protein synthesis at the ribosome level. CLINICAL USE: Treatment of Infections by sensitive germs. - Its structure has 7 hydroxyl groups, 4 ether groups, 2 alkene groups, alkane and amine groups and finally an aldehyde. - Formula: [ C21H39N7O12 ]
- Adenine was discovered in 1885 by a German biochemist, but, in 1959 the Spanish biochemist Juan Oró was able to synthesize adenine from hydrocyanic acid. - A chemical compound that cells use to make the building blocks of DNA and RNA. It is also part of many substances in the body that provide energy to cells. Adenine is a type of purine. - The structure is noted as a purine with an amine group. - Formula: [ C5H5N5 ]
- The history of homocysteine as a predictor began in 1969, when Dr. McCully described the case of a child with homocystinuria, which caused atherosclerotic vascular disease, similar to that observed in adult patients with ischemic heart disease. - It is an amino acid that the body uses to make proteins. - In its structure there is an amine group, carboxyl, and a thiol compound. - Formula: [ C4H9NO2S ]
- Amoxicillin was discovered by scientists at Beecham Research Laboratories in 1972. - Its action is to stop the growth of bacteria. This amoxicillin antibiotic does not work against colds. - It is composed of amine groups, two amides, sulfur, hydroxyl, carboxylic acid, and an aromatic ring. - Formula: [ C16H19N3O5S ]
- Fluoxetine is an antidepressant that the US FDA authorized the pharmaceutical company Eli Lilly and a company to sell. - Is used to treat depression, obsessive-compulsive disorder (nagging thoughts that do not go away), some eating disorders, and panic attacks. - In its structure there is a primary amine and an ether group. - Formula: [ C17H18F3NO ]
- Is a prescription drug that has the approval of the United States. - Analogous synthetic drug that is used in the treatment against HIV. - It has a purine in its structure in addition to having an amine and hydroxyl group. - Formula: [ C14H18N6O ]
- Arvid Carlsson was awarded the Nobel Prize in Physiology or Medicine in 2000 as it emerged that dopamine is not only a precursor to adrenaline but also a neurotransmitter. - Cardiac stimulant that increases the force of contraction of the heart muscle, causing an increase in cardiac output (volume of blood ejected by the heart per minute). - Structured by a benzene ring with this amine group making it a substituted phenethylamine and hydroxyl group. - Formula: [ C8H11NO2 ]
- The Japanese chemist Yoshito Kishi, made a simplified version of the halichondrin B molecule, called eribulin, this drug became available to treat metastatic breast cancer. -Used in Pharmaceuticals is to treat breast cancer that has spread to other parts of the body. -It is composed of a primary amino group together with a polyether, a polycyclic ether, a cyclic ketone and these can also be seen in groups such as amines and hydroxyls. - Formula: [ C40H59NO11 ]
- Johns Hopkins Medicine researchers conducted a study on 24 adults with depression applying psilocybin. With treatment, most participants had a significant reduction in their symptoms. - Generates large and rapid reductions in depressive symptoms. - Produces visual and auditory hallucinations and profound alterations of consciousness after a few hours of ingestion. - It has a benzene ring with this amine group making it a substituted phenethylamine and hydroxyl group. - Formula: [ C12H17N2O4P ]
