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GRAS was initially implemented by the FDA under the 1958 Food Additives Amendment to the Federal Food, Drug, and Cosmetic Act.
The FDA began conducting a review of GRAS substances and created GRAS affirmation.
1970's
The FDA changed its regulations to include the GRAS list.
1961
FDA proposed to replace the GRAS affirmation process with GRAS notification.
1997
Former President Richard Nixon directed the FDA to reevaluate the safety of substances that were classified as GRAS.
1969
1958
History of the GRAS Program

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