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Incidence,who is at risk?
It is a rare disease and the exact incidence is unknown. Although majority of the cases occur in females, it can affectt both genders. Lyphodema can occur at birth,before the age of 25 and after 35. The disease occurs in all ethnic groups.
Prognosis 
The condition effect for long term may be difficult to predict as severity and symptoms vary among effected individuals. In some individuals outlook depends on how chronic lymphedema as well as if complications arise.
Milroy's disease is defined as a disease that affects the normal function of the lymphatic system which drains the leaked fluids from the circulatory system back to circulation.
         Symptoms
  • Swelling of lower limbs (one or both of the legs)- lymphoedema
  • Large calibre veins, papillomatosis of the toes, hydrocele
  • Upslanting of toenail plate- ski jump toenails
Milroy Disease
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Transcript

Milroy Disease

Symptoms

  • Swelling of lower limbs (one or both of the legs)- lymphoedema
  • Large calibre veins, papillomatosis of the toes, hydrocele
  • Upslanting of toenail plate- ski jump toenails

Milroy's disease is defined as a disease that affects the normal function of the lymphatic system which drains the leaked fluids from the circulatory system back to circulation.

Prognosis The condition effect for long term may be difficult to predict as severity and symptoms vary among effected individuals. In some individuals outlook depends on how chronic lymphedema as well as if complications arise.

Incidence,who is at risk?It is a rare disease and the exact incidence is unknown. Although majority of the cases occur in females, it can affectt both genders. Lyphodema can occur at birth,before the age of 25 and after 35. The disease occurs in all ethnic groups.

InheritanceIt is a single gene autosomal dominant disorder. Other cases involve new mutations in the FLT4 gene which occurs in individuals with no history of the disorder.

Is it congenital or does it have a late onset?It is a hereditary congenital familial primary lyphodema. The condition presents itself at birth with swelling of one or both legs.

Is there any known genes for the disease?Mutations in the FLT4 gene will disrupt the production of the vascular endothelial growth factor receptor 3 (VEGFR-3) which regulates the development and maintenance of the lymphatic system.

Is there atests for this condition and what information can be gained by the results?The condition can be tested using molecular genetics approaches. genetic testing techniques include sequence analysis, gene-targated deletion/ duplication analysis and chromosome analysis.Tests results detect mutations in the FLT4 gene.

Can it be tested prenatally/ Can a carrier be tested? Prenatal testing is available, as well as post-natal tests for diagnosis purposes.Predictive genetic testing for asymptomatic, for at-risk family members can be performed.Since this is an autosomal dominant disease an individual cannot be a carrier, an individual is either affected or unaffected.

Can it be treated?Yes, by physical treatment the patient undergoes lymphatic drainage, massage and exercise. Surgical treatment is most often used. Special needs methods of toe-bandging are used to minimize toe infection. Support is provided by counseling and love and care of family.

What my be available in future with no cuurent cure being available?With no cure discoverd yet, multiple cure methods are being researched. With early diagnosis and treatment it can be controlled.

References http;//www.healthhype.com/milroy-diease-lymph-swelling-from-birthhttp;//rarediseases.info.nih.gov/diseases/7220/milroy-disease#ref_8186Brice G., Child A., Evans A., Bell R., Mansour S., Burnand K., Mortimer P. Milroy disease and the VEGFR-3 mutation phenotype. Journal of Medical Genetic, 42 (2), 98-102Butler M., Dagnais S. L.., Rockson S. G., Glover T. W. (2007). A novel VEGFR3 mutation causes Milroy disease. American Journal of Medical Genetics Part A, 143(11), 1212-1217

Reabetswe Masebe 14008794Ofentse Mathibela 14093767Laurie Guvi 12078035Kubekho Makalima 13334906

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